Subjects: Psychology >> Social Psychology submitted time 2023-03-28 Cooperative journals: 《心理科学进展》
Abstract： The neuropeptide, oxytocin (OT) has been established to play an important role in modulating social behavior and emotional processing which are of fundamental importance in our everyday life. Animal and human studies using multi-modal approaches have provided converging evidence for an important modulatory effect of exogenously administered OT on learning and memory. This effect of exogenous OT may be mediated via its receptors which are extensively distributed in key learning and memory brain networks, notably the dopamine reward pathway and limbic system. Whether OT has a facilitatory or inhibitory modulatory effect on learning and memory can be influenced by experimental paradigms and stimulus materials as well as where and when it is administered and at what dose. Future studies need to combine the respective advantages of animal models and human research and to employ standardized experimental protocols and treatment procedures to overcome current limitations in this field. Further research is also required to explore the therapeutic potential of OT for learning and memory dysfunction in psychiatric disorders.
Subjects: Psychology >> Cognitive Psychology submitted time 2021-07-11
Abstract： The neuropeptide, oxytocin (OT) has a very extensive impact on social behavior and emotional processing, including learning and memory that play a key role in our work and daily life. Animal and human studies using multi-modal technologies have provided converging evidence for an important modulatory effect of OT on learning and memory. This effect of OT may act via the binding of externally administered OT on OT receptors extensively distributed in key learning and memory brain networks namely the dopamine reward pathway and limbic system. The facilitatory or inhibitory effect of OT on learning and memory can be affected by experimental paradigms, stimulus materials, time point, dose and location of administration. In the future, it is necessary to combine the respective advantages of animal and human research, utilize standardized experimental protocols and treatment procedures to overcome current limitations in this field. Further effort should also be paid to exploring the application potential of OT in treatment of learning and memory deficits in psychiatric disorders. " " " " " "
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