Subjects: Psychology >> Social Psychology submitted time 2023-03-27 Cooperative journals: 《心理学报》
Abstract： Impulsivity is a typical characteristic of drug addiction. In addition to the problems of inhibition and executive control, the driving force from multiple dimensions is also an important reason for impulsive drug use. The psychological drive stems from a variety of sources, including reward effect, S-R related cue response through conditioning. Low levels of inhibition are insufficient to resist the effects of the drive. This leads to an unbalanced state, which results in habitual behavior tendency. Impulsivity has both a behavioral and neural basis. Although impulsivity may be a precursor of drug use, long-term use may also damage brain structures and functions related to the inhibition of impulsive behavior. There is an open question about whether these structures and functions recover after withdrawal. In this research we used multiple imaging methods to study the extent of recovery in heroin addicts who had been abstinent for several years on average. Thirty-five abstinent heroin addicts (26 males; average period of abstinence = 43.55 months) and 26 healthy controls (26 males) were recruited using advertisements in the community. The heroin group and the healthy control group were compared on multiple measures of brain structure and function related to inhibition using the imaging methods of voxel-based morphometry (VBM), amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo). Based on the amplitude of low-frequency fluctuation (ALFF), right inferior frontal gyrus (15, 60, -6) was selected as the region of interest in which to study functional connectivity (FC). Heroin addicts showed damage in inhibition-related brain structures and functions an average of 44 months after withdrawal, and the extent of damage was correlated with lifetime dose. (1) Compared to the healthy control group, the heroin group had significantly (a) lower gray matter volume (p = 0.03) and lower whole-brain volume (p = 0.05); (b) lower gray matter in the right superior frontal gyrus (pAlphaSim < 0.01); (c) higher regional homogeneity in right posterior central gyrus and lower regional homogeneity in right middle frontal gyrus of the orbitofrontal cortex (pAlphaSim < 0.01); (d) lower amplitude of low-frequency fluctuation in right inferior frontal gyrus of the orbitofrontal cortex and left hippocampus (pAlphaSim < 0.01); (e) higher functional connectivity between right inferior frontal gyrus of the orbitofrontal cortex and the right caudate, and lower functional connectivity between the right inferior frontal gyrus and right middle temporal gyrus as well left precentral gyrus (pAlphaSim < 0.01). (2) Within the heroin group, higher lifetime dose of heroin was significantly associated with lower gray matter volume in the right middle temporal gyrus and left middle cingulate (pAlphaSim < 0.01). The results showed that compared to healthy controls, heroin addicts had significant damage in brain structure and functions related to impulsivity even after an average period of 44 months of abstinence. In addition, the extent of damage was correlated with the lifetime dose of heroin. These results suggest that heroin addicts could continue to show impulsive behavior even after several years of abstinence, perhaps explaining the high rate of relapse in this population. Future research could test this conclusion by examining correlations between brain damage in areas related to inhibition and behavioral measures of impulsivity after a period of abstinence. The current evidence underscores the need to take impulsivity into account in relapse prevention programs for heroin addicts.
Subjects: Psychology >> Applied Psychology Subjects: Psychology >> Clinical and Counseling Psychology submitted time 2021-03-26
Abstract： "
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